Many people with anxiety and related disorders also experience problems related to low/depressed mood. For some people, depression is a result of the impact that anxiety and related avoidance behaviors have on their lives. For others, depression is a separate problem that can make managing anxiety more challenging. Problems with low mood can range from mild to severe, with some individuals having symptoms that meet criteria for major depressive disorder (MDD).

People with anxiety-related problems frequently experience difficulties related to sleep. These difficulties can include insomnia (problems falling asleep, staying asleep, or both), poor sleep quality, and nightmares (sometimes related to prior experiences of trauma, though not always), among others.